Scientific Research

Below you will find a collection of articles from Hematology, the ASH Education Program Book, written by experts in the field exploring topics such as personalized medicine, clinical trial design, and systematic reviews of medical literature, among others. A guide for patients about clinical trials, as well as links to other organizations that provide information on clinical trials, are also available. Patients and others are also encouraged to contact elected officials to encourage increased federal funding for scientific research.

Cellular Medicine

• Intracellular Protein Degradation: From a Vague Idea thru the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting (2006)

Markers / Diagnostics

• Tumor-Specific Genetic Lesions and Their Influence on Therapy in Pediatric Acute Lymphoblastic Leukemia (2006)
• Deeper Insights into Hematological Oncology Disorders via Single-Cell Phospho-Signaling Analysis (2006)

Molecular Medicine

• The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety (2007)
• Update on Progress and Hurdles in Novel Genetic Therapies for Hemophilia (2007)
• RNAi and Gene Therapy: A Mutual Attraction (2007)
• Deeper Insights into Hematological Oncology Disorders via Single-Cell Phospho-Signaling Analysis (2006)

Therapeutics

• Overview of Gene Therapy Clinical Progress Including Cancer Treatment With Gene-Modified T Cells (2009)
• Ten Years of Gene Therapy for Primary Immune Deficiencies (2009)
• Hematopoietic Stem Cell Gene Transfer for the Treatment of Hemoglobin Disorders (2009)
• Pharmacogenetics, Pharmacogenomics and Personalized Medicine: Are We There Yet? (2006)
• FLT3 Mutations: Biology and Treatment (2006)
• Defining and Managing Imatinib Resistance (2006)
• Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy (2005)
• The Ubiquitin Proteasome Pathway from Bench to Bedside (2005)
• Modulating the Bcl-2 Family of Apoptosis Suppressors for Potential Therapeutic Benefit in Cancer (2005) 

Scientific and Clinical Trials Methodology

• Introduction to Surrogates and Evidence-Based Mini-Reviews (2009)
• Are There Circumstances in Which Phase 2 Study Results Should Be Practice-Changing? (2007)
• Trials and Tribulations of Systematic Reviews and Meta-Analyses (2007)

Nanotechnology

• Application of Semiconductor and Metal Nanostructures In Biology and Medicine (2009)
• Dendrimer-Based Nanoparticles for Cancer Therapy (2009)
• Imaging Circulating Cells and Lymphoid Tissues With Iron Oxide Nanoparticles (2009)

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